Evaluation of inter-observer variation for computed tomography identification of childhood interstitial lung disease

Joseph Jacob^{1

2}, Catherine M Owens³, Alan S Brody⁴, Thomas Semple⁵, Tom A Watson³, Alistair Calder³, Pilar Garcia-Peña⁶, Paolo Toma⁷, Anand Devaraj⁵, Henry Walton⁸, Antonio Moreno-Galdó⁹, Paul Aurora¹⁰, Alexandra Rice¹¹, Timothy J Vece¹², Steve Cunningham¹³, Andre Altmann², Athol U Wells¹⁴, Andrew G Nicholson¹¹, Andrew Bush¹⁵

Affiliations

¹ Dept of Respiratory Medicine, University College London, London, UK.
² Centre for Medical Image Computing, University College London, London, UK.
³ Dept of Radiology, Great Ormond Street Hospital, London, UK.
⁴ Dept of Radiology, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital, Cincinnati, OH, USA.
⁵ Dept of Radiology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
⁶ Dept of Pediatric Radiology, University Hospital Vall d'Hebron, Barcelona, Spain.
⁷ Dept of Radiology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
⁸ Dept of Radiology, Royal Free London NHS Foundation Trust, London, UK.
⁹ Dept of Paediatric Respiratory Medicine, University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBERER, Spain.
¹⁰ Dept of Paediatric Respiratory Medicine, Great Ormond Street Hospital, London, UK.
¹¹ Dept of Hisopathology, Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.
¹² Dept of Pediatrics, Division of Pediatric Pulmonology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
¹³ Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
¹⁴ Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
¹⁵ Depts of Paediatrics and Paediatric Respiratory Medicine, Imperial College and Royal Brompton Hospital, London, UK.

PMID: 31367634
PMCID: PMC6661316
DOI: 10.1183/23120541.00100-2019

Evaluation of inter-observer variation for computed tomography identification of childhood interstitial lung disease

Joseph Jacob et al. ERJ Open Res. 2019.

. 2019 Jul 29;5(3):00100-2019.

doi: 10.1183/23120541.00100-2019. eCollection 2019 Jul.

Authors

Affiliations

¹ Dept of Respiratory Medicine, University College London, London, UK.
² Centre for Medical Image Computing, University College London, London, UK.
³ Dept of Radiology, Great Ormond Street Hospital, London, UK.
⁴ Dept of Radiology, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital, Cincinnati, OH, USA.
⁵ Dept of Radiology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
⁶ Dept of Pediatric Radiology, University Hospital Vall d'Hebron, Barcelona, Spain.
⁷ Dept of Radiology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
⁸ Dept of Radiology, Royal Free London NHS Foundation Trust, London, UK.
⁹ Dept of Paediatric Respiratory Medicine, University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBERER, Spain.
¹⁰ Dept of Paediatric Respiratory Medicine, Great Ormond Street Hospital, London, UK.
¹¹ Dept of Hisopathology, Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.
¹² Dept of Pediatrics, Division of Pediatric Pulmonology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
¹³ Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
¹⁴ Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
¹⁵ Depts of Paediatrics and Paediatric Respiratory Medicine, Imperial College and Royal Brompton Hospital, London, UK.

PMID: 31367634
PMCID: PMC6661316
DOI: 10.1183/23120541.00100-2019

Abstract

Making chILD diagnoses on CT is poorly reproducible, even amongst sub-specialists. CT might best improve diagnostic confidence in a multidisciplinary team setting when augmented with clinical, functional and haematological results. http://bit.ly/327jRCw.

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Conflict of interest statement

Conflict of interest: J. Jacob reports personal fees from Boehringer Ingelheim (advisory board fees) and Roche, outside the submitted work. Conflict of interest: C.M. Owens reports personal fees from Boehringer Ingelheim, outside the submitted work. Conflict of interest: A.S. Brody reports personal fees from Vertex, outside the submitted work. Conflict of interest: T. Semple reports personal fees from Vertex, outside the submitted work. Conflict of interest: T.A. Watson has nothing to disclose. Conflict of interest: A. Calder has nothing to disclose. Conflict of interest: P. Garcia-Peña has nothing to disclose. Conflict of interest: P. Toma has nothing to disclose. Conflict of interest: A. Devaraj reports personal fees from Boehringer Ingelheim, Roche, and GSK, outside the submitted work. Conflict of interest: H. Walton has nothing to disclose. Conflict of interest: A. Moreno-Galdó reports personal fees from Abbvie, Actelion, and Novartis, outside the submitted work. Conflict of interest: P. Aurora has nothing to disclose. Conflict of interest: A. Rice reports personal fees from AbbVie, outside the submitted work. Conflict of interest: T.J. Vece has nothing to disclose. Conflict of interest: S. Cunningham reports personal fees from Boehringer Ingelheim, outside the submitted work. Conflict of interest: A. Altmann has nothing to disclose. Conflict of interest: A.U. Wells reports personal fees from Intermune (advisory board and speaker fees), Boehringer Inlgeheim (advisory board and speaker fees), Gilead (advisory board fees), MSD (advisory board fees), Roche (advisory board and speaker fees), Bayer (advisory board and speaker fees), and Chiesi (speaker fees), outside the submitted work. Conflict of interest: A.G. Nicholson reports personal fees from Boehringer Ingelheim (advisory board fees), Roche, Medical Quantitative Image analysis, and Galapagos, outside the submitted work. Conflict of interest: A. Bush has nothing to disclose.

References

1. Bush A, Cunningham S, de Blic J, et al. . European protocols for the diagnosis and initial treatment of interstitial lung disease in children. Thorax 2015; 70: 1078–1084. - PubMed
1. Rice A, Tran-Dang M-A, Bush A, et al. . Diffuse lung disease in infancy and childhood: expanding the chILD classification. Histopathology 2013; 63: 743–755. - PubMed
1. Fan LL, Dishop MK, Galambos C, et al. . Diffuse lung disease in biopsied children 2 to 18 years of age. Application of the chILD classification scheme. Ann Am Thorac Soc 2015; 12: 1498–1505. - PMC - PubMed
1. Copley SJ, Coren M, Nicholson AG, et al. . Diagnostic accuracy of thin-section CT and chest radiography of pediatric interstitial lung disease. AJR 2000; 174: 549–554. - PubMed
1. Kurland G, Deterding RR, Hagood JS, et al. . An Official American Thoracic Society Clinical Practice Guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy. Am J Respir Crit Care Med 2013; 188: 376–394. - PMC - PubMed

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Evaluation of inter-observer variation for computed tomography identification of childhood interstitial lung disease

Affiliations

Evaluation of inter-observer variation for computed tomography identification of childhood interstitial lung disease

Authors

Affiliations

Abstract

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources