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. 2019 Jul 29;5(3):00064-2019.
doi: 10.1183/23120541.00064-2019. eCollection 2019 Jul.

A randomised controlled trial to investigate the use of high-frequency airway oscillations as training to improve dyspnoea in COPD

Enya Daynes  1   2   3 , Neil Greening  1   2   3 , Salman Sidiqqui  2   3 , Sally Singh  1   2   3
Affiliations

A randomised controlled trial to investigate the use of high-frequency airway oscillations as training to improve dyspnoea in COPD

Enya Daynes et al. ERJ Open Res. .

Erratum in

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is characterised by expiratory flow limitation resulting in symptomatic dyspnoea, sputum retention and ventilation heterogeneity. Changes in breathing mechanics affect the ability of respiratory muscles to respond to the ventilatory demands, increasing the sensation of dyspnoea. A high-frequency airway oscillating device has been developed to combine respiratory muscle training and oscillations to improve dyspnoea and sputum retention within COPD.

Methods and analysis: Patients with symptomatic COPD (Medical Research Council Breathlessness scale grade ≥2) will be recruited to a double-blind, randomised, sham-controlled trial. Both groups will follow an 8-week intervention phase using the device three times per day for 5 min at a time. This will be recorded in a self-reported diary. The device applies a flow resistive load and oscillations for combined training. Those receiving the sham device will follow the same protocol; however, the mechanism of action will be removed from the device. Improvements in the Chronic Respiratory Questionnaire-Dyspnoea domain will be the primary outcome measure. Secondary outcomes will explore respiratory muscle function, health-related quality of life, exercise capacity and physical activity. The Lung Clearance Index will be an exploratory outcome. Outcomes will be explored using the most appropriate statistical test, dependent on the sample distribution. Focus groups will be an exploratory outcome and analysed by thematic analysis.

Ethics and dissemination: Ethical approval has been obtained from the East Midlands-Leicester South Research Ethics Committee and the trial has been registered through the ISRCTN Registry. The study results will be disseminated to the appropriate stakeholders through presentations, conferences and peer-reviewed journals.

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Conflict of interest statement

Conflict of interest: E. Daynes reports grants from Actegy Ltd during the conduct of the study. Conflict of interest: N. Greening has nothing to disclose. Conflict of interest: S. Sidiqqui has nothing to disclose. Conflict of interest: S. Singh reports grants from Actegy Ltd during the conduct of the study.

Figures

FIGURE 1
FIGURE 1
Flow diagram of study procedures in patients with symptomatic chronic obstructive pulmonary disease (COPD). CRQ-SR: self-reported Chronic Respiratory Questionnaire; CAT: COPD Assessment Test.
FIGURE 2
FIGURE 2
Top (left to right): Aerosure Medic active device, and device aerosol head anterior and inferior views. Bottom (left to right): Aerosure Medic sham device, and device aerosol head anterior and inferior views. Note mechanism removed from sham device.
FIGURE 3
FIGURE 3
Patient using the Aerosure Medic.
FIGURE 4
FIGURE 4
Patient performing a multiple breath washout measurement.
See this image and copyright information in PMC

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