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. 2019 Aug 20;132(16):1990-1992.
doi: 10.1097/CM9.0000000000000377.

Anesthesia-induced developmental neurotoxicity in children: past, present, and future

Affiliations

Anesthesia-induced developmental neurotoxicity in children: past, present, and future

Liu-Jia-Zi Shao et al. Chin Med J (Engl). .

Abstract

Supplemental Digital Content is available in the text

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References

    1. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999; 283:70–74. doi: 10.1126/science.283.5398.70. - PubMed
    1. Sanders RD, Hassell J, Davidson AJ, Robertson NJ, Ma D. Impact of anaesthetics and surgery on neurodevelopment: an update. Br J Anaesth 2013; 110 suppl 1:i53–i72. doi: 10.1093/bja/aet054. - PMC - PubMed
    1. Xie SN, Ye H, Li JF, An LX. Sevoflurane neurotoxicity in neonatal rats is related to an increase in the GABAA R alpha1/GABAA R alpha2 ratio. J Neurosci Res 2017; 95:2367–2375. doi: 10.1002/jnr.24118. - PubMed
    1. Walkden GJ, Pickering AE, Gill H. Assessing long-term neurodevelopmental outcome following general anesthesia in early childhood: challenges and opportunities. Anesth Analg 2019; 128:681–694. doi: 10.1213/ANE.0000000000004052. - PMC - PubMed
    1. Vinson AE, Houck CS. Neurotoxicity of anesthesia in children: prevention and treatment. Curr Treat Options Neurol 2018; 20:51.doi: 10.1007/s11940-018-0536-z. - PubMed