. 2019 Sep 1:1125:121729.

doi: 10.1016/j.jchromb.2019.121729. Epub 2019 Jul 23.

Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel

Roy Gerona¹, Anita Wen², David Aguilar², Jamie Shum³, Andrew Reckers², Peter Bacchetti⁴, Monica Gandhi⁵, John Metcalfe⁶

Affiliations

¹ Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California, San Francisco (UCSF), San Francisco, CA, 94115, United States of America. Electronic address: Roy.Gerona@ucsf.edu.
² Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California, San Francisco (UCSF), San Francisco, CA, 94115, United States of America.
³ Department of Medicine, Hair Analysis Laboratory, University of California San Francisco (UCSF), San Francisco, CA 94143, United States of America.
⁴ Department of Epidemiology and Biostatistics, University of California San Francisco (UCSF), San Francisco, CA 94143, United States of America.
⁵ Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco (UCSF), San Francisco, CA 94110, United States of America.
⁶ Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco (UCSF), San Francisco, CA 94110, United States of America.

PMID: 31369929
PMCID: PMC6711392
DOI: 10.1016/j.jchromb.2019.121729

Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel

Roy Gerona et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2019.

. 2019 Sep 1:1125:121729.

doi: 10.1016/j.jchromb.2019.121729. Epub 2019 Jul 23.

Authors

Roy Gerona¹, Anita Wen², David Aguilar², Jamie Shum³, Andrew Reckers², Peter Bacchetti⁴, Monica Gandhi⁵, John Metcalfe⁶

Affiliations

¹ Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California, San Francisco (UCSF), San Francisco, CA, 94115, United States of America. Electronic address: Roy.Gerona@ucsf.edu.
² Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California, San Francisco (UCSF), San Francisco, CA, 94115, United States of America.
³ Department of Medicine, Hair Analysis Laboratory, University of California San Francisco (UCSF), San Francisco, CA 94143, United States of America.
⁴ Department of Epidemiology and Biostatistics, University of California San Francisco (UCSF), San Francisco, CA 94143, United States of America.
⁵ Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco (UCSF), San Francisco, CA 94110, United States of America.
⁶ Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco (UCSF), San Francisco, CA 94110, United States of America.

PMID: 31369929
PMCID: PMC6711392
DOI: 10.1016/j.jchromb.2019.121729

No abstract available

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Figures

**Figure 1.**
Representative extracted ion chromatogram of analytes in the MDR TB drug panel spiked in a blank hair matrix (EMB= ethambutol; INH= isoniazid; PZA= pyrazinamide; ETH= ethionamide; PTH= prothinamide; LFX= levofloxacin; MFX= moxiflloxacin; LZD= linezolid; PTM= pretomanid; BDQ= bedaquiline; CFZ= clofazimine). INH, LZD, LFX, MFX and LZD were spiked at 20 ng/mg hair while BDQ, CLF, EMB, ETH, PTH and PTM were spiked at 2 ng/mg hair.

**Figure 2.**
Structural formula of anti-TB drugs in the MDR TB drug panel.

See this image and copyright information in PMC

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References

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Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel

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Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel

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