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. 1988 Sep-Oct;29(5):548-52.
doi: 10.1111/j.1528-1157.1988.tb03759.x.

Valproate in the treatment of absence epilepsy in children: a study of dose-response relationships

G Braathen  1 , K Theorell, A Persson, A Rane
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Valproate in the treatment of absence epilepsy in children: a study of dose-response relationships

G Braathen et al. Epilepsia. 1988 Sep-Oct.

Abstract

Seven children with absence epilepsy were treated with valproate (VPA). All but one child became free of absence seizures during VPA monotherapy. EEG was recorded for 24 h before start of VPA treatment and repeatedly during treatment. Correlation between plasma VPA concentration and reduction of the number of epileptic discharges was significant. Plasma concentration of 440-660 microM VPA was needed to achieve at least 50% reduction of seizure activity.

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