Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 31;55(8):426.
doi: 10.3390/medicina55080426.

Innovative Spine Implants for Improved Augmentation and Stability in Neoplastic Vertebral Compression Fracture

Francois H Cornelis  1 , Quentin Joly  2 , Maud Nouri-Neuville  3 , Mohamed Ben-Ammar  3 , Bruno Kastler  4 , Adrian Kastler  5   6 , Nicolas Amoretti  7 , Olivier Hauger  8
Affiliations
Review

Innovative Spine Implants for Improved Augmentation and Stability in Neoplastic Vertebral Compression Fracture

Francois H Cornelis et al. Medicina (Kaunas). .

Abstract

Background and objectives: Tumor-related vertebral compression fractures often result in severe back pain as well as progressive neurologic impairment and additional morbidities. The fixation of these fractures is essential to obtain good pain relief and to improve the patients' quality of life. Thus far, several spine implants have been developed and studied. The aims of this review were to describe the implants and the techniques proposed to treat cancer-related vertebral compression fractures and to compile their safety and efficacy results. Materials and Methods: A systematic MEDLINE/PubMed literature search was performed, time period included articles published between January 2000 and March 2019. Original articles were selected based on their clinical relevance. Results: Four studies of interest and other cited references were analyzed. These studies reported significant pain and function improvement as well as kyphotic angle and vertebral height restoration and maintain for every implant and technique investigated. Conclusions: Although good clinical performance is reported on these devices, the small numbers of studies and patients investigated draw the need for further larger evaluation before drawing a definitive treatment decision tree to guide physicians managing patients presenting with neoplastic vertebral compression fracture.

Keywords: bone; cancer; interventional oncology; vertebral compression fracture; vertebroplasty.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Vertebral Body Stent® (VBS®) deployment procedure.
Figure 2
Figure 2
KIVA® implant design and delivery ancillaries.
Figure 3
Figure 3
SpineJack® implantation procedure
Figure 4
Figure 4
Views of V-STRUT© implants in a vertebra (A) perspective, (B) top view, (C) side view, (D) back view
Figure 5
Figure 5
Pre-operative CT scans of the L2 metastatic lesion (A) sagittal, (B) transversal, and immediate post-operative fluoroscopic images of the PEEK (polyetheretherketone) implants (C) sagittal, (D) transversal.
See this image and copyright information in PMC

References

    1. Hazzard M.A., Huang K.T., Toche U.N., Ugiliweneza B., Patil C.G., Boakye M., Lad S.P. Compression fractures and impact on US healthcare resource utilization. Asian Spine J. 2014;8:605. doi: 10.4184/asj.2014.8.5.605. - DOI - PMC - PubMed
    1. Li C., Zhang H.-B., Zhang H., Li Q., Zhang J., Wang J., Guo K.-J., Wang L.-X. Severe pathological fractures caused by vertebral hemangiomas with posterior decompression, bone cement augmentation and internal fixation. Orthop. Traumatol. Surg. Res. 2016;102:489–494. doi: 10.1016/j.otsr.2016.01.024. - DOI - PubMed
    1. Becker N. Side Effects of Medical Cancer Therapy. 2nd ed. Springer; Berlin/Heidelberg, Germany: 2018. Epidemiology of Multiple Myeloma; pp. 277–284. - DOI
    1. Ali T., Bornemann R., Roessler P.P., Sander K., Wirtz D.C., Pflugmacher R., Frey S.P. Mid-term outcomes after radiofrequency-targeted vertebral augmentation in the treatment of myeloma associated vertebral fractures. Technol. Heal. Care. 2016;24:745–751. doi: 10.3233/THC-161222. - DOI - PubMed
    1. Yuh W.T., Zachar C.K., Barloon T.J., Sato Y., Sickels W.J., Hawes D.R. Vertebral compression fractures: Distinction between benign and malignant causes with MR imaging. Radiology. 1989;172:215–218. doi: 10.1148/radiology.172.1.2740506. - DOI - PubMed

MeSH terms