Induced engulfment of Neisseria gonorrhoeae by tissue culture cells
- PMID: 3137172
- PMCID: PMC259598
- DOI: 10.1128/iai.56.9.2512-2514.1988
Induced engulfment of Neisseria gonorrhoeae by tissue culture cells
Abstract
Engulfment of gonococci by mammalian tissue culture cells was examined as a model of the penetration of host cells in gonorrhea. Engulfment required viable organisms; killing the gonococci with heat or refrigeration abolished the process. Engulfment also required tissue culture cell microtubule- and microfilament-dependent movement; treating the cells with cytochalasin B (0.5 micrograms/ml) or demecolcine (Colcemid; Ciba-Geigy AG, Basel, Switzerland) (10 micrograms/ml) also prevented his process.
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