Steering CARs in the right direction

Anna Dart¹

Affiliations

Comment

Anna Dart. Nat Rev Cancer. 2019 Sep.

. 2019 Sep;19(9):487.

doi: 10.1038/s41568-019-0189-6.

Anna Dart¹

No abstract available

Comment on

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells.
Mestermann K, Giavridis T, Weber J, Rydzek J, Frenz S, Nerreter T, Mades A, Sadelain M, Einsele H, Hudecek M. Mestermann K, et al. Sci Transl Med. 2019 Jul 3;11(499):eaau5907. doi: 10.1126/scitranslmed.aau5907. Sci Transl Med. 2019. PMID: 31270272 Free PMC article.
Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor.
Ma L, Dichwalkar T, Chang JYH, Cossette B, Garafola D, Zhang AQ, Fichter M, Wang C, Liang S, Silva M, Kumari S, Mehta NK, Abraham W, Thai N, Li N, Wittrup KD, Irvine DJ. Ma L, et al. Science. 2019 Jul 12;365(6449):162-168. doi: 10.1126/science.aav8692. Science. 2019. PMID: 31296767 Free PMC article.
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.
Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV. Choi BD, et al. Nat Biotechnol. 2019 Sep;37(9):1049-1058. doi: 10.1038/s41587-019-0192-1. Epub 2019 Jul 22. Nat Biotechnol. 2019. PMID: 31332324

1. Choi, B. D. et al. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0192-1 (2019) - DOI - PubMed
1. Ma, L. et al. Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor. Science 365, 162–168 (2019)
1. Mestermann, K. et al. The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells. Sci. Transl Med. 11, eaau5907 (2019) - DOI