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. 2019 Jul;37(3):234-241.
doi: 10.2337/cd18-0063.

Practical Insights Into Improving Adherence to Metformin Therapy in Patients With Type 2 Diabetes

Elena A Christofides  1
Affiliations

Practical Insights Into Improving Adherence to Metformin Therapy in Patients With Type 2 Diabetes

Elena A Christofides. Clin Diabetes. 2019 Jul.

Abstract

IN BRIEF Adherence to metformin-based treatment regimens for type 2 diabetes is currently suboptimal due to a complex array of patient-, treatment-, and physician-related barriers, including physical and psychological swallowing difficulties associated with large tablets and gastrointestinal disturbances. Patients often avoid discussing these issues with their primary care providers, and delays in addressing them can lead to reduced glycemic control. This article reviews the issues commonly responsible for poor adherence to metformin and presents strategies to improve compliance, including shared decision-making and the use of different metformin formulations, including liquid metformin.

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References

    1. International Diabetes Federation IDF Diabetes Atlas. 8th ed. Brussels, Belgium, International Diabetes Federation, 2017. Available from www.diabetesatlas.org. Accessed 20 September 2018
    1. Brundisini F, Vanstone M, Hulan D, DeJean D, Giacomini M. Type 2 diabetes patients’ and providers’ differing perspectives on medication nonadherence: a qualitative meta-synthesis. BMC Health Serv Res 2015;15:516. - PMC - PubMed
    1. World Health Organization Adherence to Long-Term Therapies: Evidence for Action . Geneva, Switzerland, World Health Organization, 2003
    1. Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care 2004;27:1218–1224 - PubMed
    1. Iglay K, Cartier SE, Rosen VM, et al. . Meta-analysis of studies examining medication adherence, persistence, and discontinuation of oral antihyperglycemic agents in type 2 diabetes. Curr Med Res Opin 2015;31:1283–1296 - PubMed