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. 2019 Jul;37(3):250-259.
doi: 10.2337/cd18-0040.

Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease

Kenneth S Hershon  1 , Barbara R Hirsch  1 , Ola Odugbesan  2
Affiliations

Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease

Kenneth S Hershon et al. Clin Diabetes. 2019 Jul.

Abstract

IN BRIEF This article reviews the evidence regarding the impact of postprandial glucose (PPG) on overall A1C and its relation to cardiovascular disease (CVD). To date, four randomized, controlled trials have evaluated the impact of PPG reduction on CVD; however, only one of these successfully demonstrated a positive effect. Despite this, epidemiological evidence does indicate a cardiovascular benefit of PPG reduction, and agents that can be used to manage PPG in people with type 2 diabetes are also discussed.

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Figures

FIGURE 1.
FIGURE 1.
Relative contributions of postprandial (□) and fasting (■) hyperglycemia (%) to the overall diurnal hyperglycemia over quintiles of A1C. aSignificant difference between FPG and PPG (paired t test). bSignificantly different from all other quintiles (analysis of variance [ANOVA]). cSignificantly different from quintile 5 (ANOVA). Reprinted with permission from ref. 8.
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