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. 2019 Jul 9:13:1157-1163.
doi: 10.2147/OPTH.S208256. eCollection 2019.

Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

L Caretti  1 , A La Gloria Valerio  1 , R Piermarocchi  1 , G Badin  1 , G Verzola  1 , F Masarà  1 , T Scalora  2 , C Monterosso  3
Affiliations

Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

L Caretti et al. Clin Ophthalmol. .

Abstract

Purpose: To evaluate the effects of carbomer sodium hyaluronate trehalose (CHT) and sodium hyaluronate eye drops on tear film stability and ocular discomfort after cataract surgery.

Setting: Santa Maria della Misericordia Hospital, Rovigo, Italy.

Design: Prospective randomized case-control study.

Patients and methods: This study enrolled sixty patients scheduled for unilateral cataract surgery. After phacoemulsification, subjects received carbomer sodium hyaluronate trehalose (trehalose group) or sodium hyaluronate tears (HG group) substitute and were assessed through objective (break up time, corneal and conjunctival staining) and subjective (OSDI questionnaire) clinical evaluations after a two times a day topical administration. Outcome measures were collected preoperatively (baseline), one week (day 7) and 1 month (day 30) after surgery. Finally, each patient was asked to give his personal treatment satisfaction score.

Results: Trehalose group showed a steeper break up time (BUT) increase compared to patient treated with hyaluronic acid (P<0.001). OSDI questionnaire presented a opposite trend, trehalose patients evidenced a significantly major improvement (P<0.001), and in seven days mean values reduced by more than three times. Fluorescein staining reduction was documented with both treatments, although there was no statistically significant difference between groups. Finally CHT resulted in a significantly greater global satisfaction score (P<0.001).

Conclusions: CHT was effective and well tolerated in reducing dry eye disease symptoms and improving the clinical outcome after cataract surgery. On some parameters (BUT, OSDI), this new formulation was more effective than commonly used sodium hyaluronate in treating ocular irritation and tear film alterations.

Keywords: artificial tears; cataract surgery; tear film instability; trehalose.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Mean TBUT pre-operatively and seven days and 30 days post-operatively. The bars represent standard deviation of the mean. Abbreviations: HG, Hyaluronate group; Trehalose, Trehalose group; BUT, break up time.
Figure 2
Figure 2
Mean OSDI score pre-operatively and seven days and 30 days post operatively. The bars represent standard deviation of the mean. Abbreviations: HG, Hyaluronate group; Trehalose, Trehalose group; OSDI, ocular surface disease index.
Figure 3
Figure 3
Mean Oxford score pre-operatively and seven days and 30 days post-operatively. The bars represent standard deviation of the mean. Abbreviations: HG, Hyaluronate group; Trehalose, Trehalose group; Oxford, Oxford scale score.
See this image and copyright information in PMC

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