Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul 10:13:1083-1092.
doi: 10.2147/PPA.S194667. eCollection 2019.

Effectiveness of low-cost reminder package combined with case-based health education to improve hypertensive patients' medication adherence: a clustered randomized controlled trial

Ying Shen  1 , Taotao Wang  1 , Min Gao  1 , Xiaorou Zhu  1 , Xing Zhang  1 , Chao He  2 , Yindong Li  2 , Xinying Sun  1
Affiliations

Effectiveness of low-cost reminder package combined with case-based health education to improve hypertensive patients' medication adherence: a clustered randomized controlled trial

Ying Shen et al. Patient Prefer Adherence. .

Abstract

Purpose: Medication adherence (MA) is a key factor for hypertensive patients' blood pressure control and forgetfulness is one of the main reasons that cause medication non-adherence. If effective, low-cost reminder package (LCRP) has great potentials for large-scale promotion. Therefore, this study aims to evaluate the effectiveness of combining LCRP and health education to improve MA among hypertensive patients.

Patients and methods: A clustered randomized controlled trial was performed in Beijing. A total of 518 hypertensive patients recruited from 8 community health care centers were randomized to receive LCRP combined with case-based health education or usual care. Randomization was performed at community level. Multilevel modeling was used to evaluate the study effect.

Results: MA scores did not differ significantly at baseline between the intervention group and the control group. The results of multilevel modeling indicated that MA scores increased more in the intervention group, and the intervention effect on MA was 0.287 (95% CI: [0.103, 0.471], P=0.002). Patients' systolic blood pressure (SBP) and diastolic blood pressure (DBP) were not improved (SBP: difference=0.536, 95% CI [-3.207, 4.278]; DBP: difference=-0.927, 95% CI [-3.283, 1.428]).

Conclusion: LCRP combined with case-based health education could significantly improve hypertensive patients' MA.

Keywords: case-based health education; low-cost reminder package; medication adherence; multilevel modeling.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Kotchen TA. Hypertension control: trends, approaches, and goals. Hypertension. 2007;49(1):19–20. doi:10.1161/01.HYP.0000250394.05703.06 - DOI - PubMed
    1. Kearney P, Whelton M, Reynolds K, Muntner P, Whelton P, HE J. Global burden of hypertension: analysis of worldwide data. The Lancet. 2005;365(9455):217–223. doi:10.1016/S0140-6736(05)70151-3 - DOI - PubMed
    1. Collaboration NRF. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Collaboration NRF, ed. The Lancet. 2017;389(10064):37–55. doi:10.1016/S0140-6736(16)31919-5 - DOI - PMC - PubMed
    1. Lawes CMM, Hoorn SV, Rodgers A. Global burden of blood-pressure-related disease, 2001. The Lancet. 2008;371(9623):1513–1518. doi:10.1016/s0140-6736(08)60655-8 - DOI - PubMed
    1. Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the global burden of disease study 2010. The Lancet. 2012;380(9859):2224–2260. doi:10.1016/S0140-6736(12)61766-8 - DOI - PMC - PubMed