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Meta-Analysis
. 2019 Jul 12:14:1243-1254.
doi: 10.2147/CIA.S210062. eCollection 2019.

Different durations of cognitive stimulation therapy for Alzheimer's disease: a systematic review and meta-analysis

Juexuan Chen #  1 , Yuting Duan #  1   2 , Huanjie Li  3 , Liming Lu  1 , Jihong Liu  3 , Chunzhi Tang  1
Affiliations
Meta-Analysis

Different durations of cognitive stimulation therapy for Alzheimer's disease: a systematic review and meta-analysis

Juexuan Chen et al. Clin Interv Aging. .

Abstract

Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer's disease (AD).

Methods: A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool.

Results: Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST.

Conclusion: Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.

Keywords: Alzheimer’s disease; cognitive stimulation therapy; cognitive symptom; meta-analysis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
PRISMA flow chart of the literature screening and selection process. Abbreviations: AD, Alzheimer's disease; RCTS, randomized controlled trials.
Figure 2
Figure 2
Risk of bias graph.
Figure 3
Figure 3
Risk of bias summary.
Figure 4
Figure 4
Forests plots for comparison of CST plus ChEIs versus ChEIs alone assessed by MMSE. Abbreviations: CST, cognitive stimulation therapy; ChEIs, acetylcholinesterase inhibitor; MMSE, Mini-Mental State Examination.
Figure 5
Figure 5
Forests plots for comparison of CST plus ChEIs versus ChEIs alone assessed by NPI. Abbreviations: CST, cognitive stimulation therapy; ChEIs, acetylcholinesterase inhibitor; NPI, neuropsychiatric inventory.
Figure 6
Figure 6
Forest plots for the comparison of short-term/maintenance/long-term CST plus ChEIs and ChEIs alone in MMSE. Abbreviations: CST, cognitive stimulation therapy; ChEIs, acetylcholinesterase inhibitor; MMSE, Mini-Mental State Examination.
See this image and copyright information in PMC

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