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. 1988 Jun;79(6):687-90.
doi: 10.1111/j.1349-7006.1988.tb02223.x.

Medullasin induces activated killer cells from human lymphocytes

Y Aoki  1
Affiliations

Medullasin induces activated killer cells from human lymphocytes

Y Aoki. Jpn J Cancer Res. 1988 Jun.

Abstract

Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer-sensitive and -resistant target cells. The optimum concentration of medullasin was 20 micrograms/ml when lymphocytes were treated with the protease at 37 degrees C for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment.

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References

    1. ) Lotze , M. T. , Grimm , E. A. , Mazumder , A. , Strausser , J. L. and Rosenberg , S. A.Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T‐cell growth factor . Cancer Res. , 41 , 4420 – 4425 ( 1981. ). - PubMed
    1. ) Grimm , E. A. , Mazumder , A. , Zhang , H. Z. and Rosenberg , S. A.Lymphokine‐activated killer cell phenomenon. Lysis of natural killer‐resistant fresh tumor cells by inteleukin 2‐activated autologous human peripheral blood lymphocytes . J. Exp. Med. , 155 , 1823 – 1841 ( 1982. ). - PMC - PubMed
    1. ) Grimm , E. A. , Robb , R. , Roth , J. A. , Neckers , L. M. , Lachman , L. B. , Wilson , D. J. and Rosenberg , S. A.Lymphokine‐activated killer cell phenomenon. III. Evidence that IL‐2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine‐activated killer cells . J. Exp. Med. , 158 , 1356 – 1361 ( 1983. ). - PMC - PubMed
    1. ) Trinchieri , G. , Matsumoto‐Kobayashi , M. , Clark , S. C. , Seehra , J. , London , L. and Perussia , B.Response of resting human peripheral blood natural killer cells to interleukin‐2 . J. Exp. Med. , 160 , 1147 – 1169 ( 1984. ). - PMC - PubMed
    1. ) Oshimi , K. , Oshimi , Y. , Akutzu , M. , Saito , H. and Mizoguchi , H.Cytotoxicity of interleukin 2‐activated lymphocytes for leukemia and lymphoma calls . Blood , 68 , 938 – 948 ( 1986. ). - PubMed

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