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. 2019 Jul-Aug;35(4):940-944.
doi: 10.12669/pjms.35.4.83.

Injection of immunoglobulin in the treatment process of children with severe pneumonia

Liping Chen  1 , Xuehai Qi  2 , Ruiying Li  3 , Xudong Wang  4 , Baohai Shi  5 , Qingmei Meng  6
Affiliations

Injection of immunoglobulin in the treatment process of children with severe pneumonia

Liping Chen et al. Pak J Med Sci. 2019 Jul-Aug.

Abstract

Objective: To observe the effect of intravenous infusion of immune globulin in the treatment of children with severe pneumonia.

Methods: Ninety-eight children with severe pneumonia who received treatment in our hospital between April 2015 and December 2016 were selected, and they were grouped into a control group and an treatment group, 49 each group. The control group received conventional treatment. The treatment group was additionally treated with immune globulin on the basis of conventional treatment. The humoral immune indicators were detected using immunoturbidimetric assay, and the inflammatory reaction indicators were detected using enzyme-linked immunoabsorbent kit. The overall efficacy, clinical symptoms, humoral immunity and inflammatory response were compared between the two groups.

Results: The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The cough, rale and fever of the treatment group disappeared faster than those of the control group, the relief of cardiac failure was also faster in the treatment group (P<0.05). The immunoglobulin G (Ig G), Ig A and Ig M of patients in the two groups compared before treatment, and no significant difference was found (P>0.05). The Ig G level of the treatment group was higher than that of the control group after treatment (P<0.05). The comparison of Ig A and Ig M between the two groups indicated no significant difference (P>0.05). The two groups had no significant differences in the content of tumor necrosis factor (TNF)-α, C-reactive protein (CRP), soluble intercellular adhesion molecule (SICAM)-1 and interferon (IFN)-γ (P>0.05) before treatment, but the content of the treatment group was significantly higher than that of the control group (P<0.01).

Conclusion: Immunoglobulin was significantly effective in the adjuvant treatment of children with severe pneumonia, and it can rapidly improve the improvement of symptoms, enhance immune function and inhibit inflammatory reaction; therefore it is worth promotion.

Keywords: Children; Immune globulin; Severe pneumonia; Treatment.

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Conflict of interest statement

Declaration of interest: None

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