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Editorial
. 2019 Jun;11(6):2188-2191.
doi: 10.21037/jtd.2019.06.07.

The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics

Aysegul Balyimez  1 , Kevin L Stephans  2 , Mohamed E Abazeed  1   2 , Omar Y Mian  1   2
Affiliations
Editorial

The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics

Aysegul Balyimez et al. J Thorac Dis. 2019 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: ME Abazeed reports the following COI: Siemens Healthcare: Grant Support; Bayer AG: Grant Support, Travel Support, Honorarium. The other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Molecular profiling reveals an early signature of cancer progression. Teixeira et al. (8) show that distinctive epigenomic and transcriptomic changes associated with future progression are superimposed on a background of genomic instability in early carcinogenesis. CIS lesions were followed with serial biopsy and genomic profiling of the index lesion was performed with pathological evidence of progression to invasive cancer (50%) or regression to low-grade dysplasia or normal epithelium (30%). Genomic alterations, gene expression, and methylation profiles associated with progressive lesions were used in predictive modeling to forecast development of invasive cancer. CIS, carcinoma in situ.
See this image and copyright information in PMC

Comment on

  • Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.
    Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM. Teixeira VH, et al. Nat Med. 2019 Mar;25(3):517-525. doi: 10.1038/s41591-018-0323-0. Epub 2019 Jan 21. Nat Med. 2019. PMID: 30664780 Free PMC article.

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