Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;114(4):369-72.
doi: 10.1007/BF02128180.

Activity of glycogen synthase and phosphorylase and glucose 6-phosphate content in renal clear cell carcinomas

D Mayer  1 , P Bannasch
Affiliations

Activity of glycogen synthase and phosphorylase and glucose 6-phosphate content in renal clear cell carcinomas

D Mayer et al. J Cancer Res Clin Oncol. 1988.

Abstract

Eleven renal clear cell carcinomas were investigated with regard to their glycogen and glucose 6-phosphate (G6P) content and the activities of glycogen synthase and phosphorylase. Compared to normal cortex from the same kidneys, all tumours revealed increased glycogen and G6P content. The activities of phosphorylase a and b as well as of synthase R and D were also increased. Synthase I activity, however, was reduced. It was concluded that in these tumours glycogen synthesis may preferentially be catalyzed by synthase R which is activated by G6P. These findings agree with those in some other glycogenotic tissues and support the concept that an accumulation of G6P is associated with excessive storage of glycogen in preneoplastic and neoplastic lesions.

PubMed Disclaimer

References

    1. Bannasch P, Krech R, Zerban H (1978) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholinvergifteten Ratten. II. Tubuläre Glykogenose und die Genese von klar- und acidophilzelligen Tumoren. Z Krebsforsch 92:63–86
    1. Bannasch P, Benner U, Hacker HJ, Klimek, F, Mayer D, Moore M, Zerban H (1981) Cytochemical and biochemical microanalysis of carcinogenesis. Histochem J 13:799–820 - PubMed
    1. Bannasch P, Hacker HJ, Tsuda H, Zerban H (1986) Aberrant regulation of carbohydrate metabolism and metamorphosis during renal carcinogenesis. Adv Enzyme Regul 25:279–296 - PubMed
    1. Darton SJ (1969) The conversion of injected glucose into renal glycogen and mucopolysaccharides. An autoradiographic study of rabbits in various states of hydration. Z Zellforsch 102: 273–282 - PubMed
    1. Enzmann H, Dettler T, Ohlhauser D, Bannasch P (1988) Elevation of glucose 6-phosphate in early stages of hepatocarcinogenesis induced in rats by N-nitrosomorpholine. Horm Metabol Res 20:128–129 - PubMed

LinkOut - more resources