Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jul 17:26:100971.
doi: 10.1016/j.eucr.2019.100971. eCollection 2019 Sep.

Multiple myeloma with testicular involvement: A case report

Kaori Yamashita  1 , Toshihide Horiuchi  1 , Akihiro Hayashida  1 , Hidekazu Tachibana  1 , Daisuke Toki  1 , Tsunenori Kondo  1
Affiliations
Case Reports

Multiple myeloma with testicular involvement: A case report

Kaori Yamashita et al. Urol Case Rep. .

Abstract

A case of multiple myeloma with testicular involvement is rare. We report a 72-year-old male with testicular infiltration as extramedullary disease of IgD λ-type multiple myeloma. The patient received systemic treatment, which included high orchiectomy, anticancer chemotherapy, and radiation therapy for bone metastasis. Eight months after the initial diagnosis, he remains alive. The testis is a rare location for extramedullary disease of multiple myeloma. Testicular involvement of multiple myeloma indicates a poor prognosis. The particular treatment strategy for extramedullary disease in multiple myeloma remains unclear. Testicular involvement of multiple myeloma is reviewed and discussed in this paper.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Computer tomography image demonstrated an enlarged left testis and hydrocele (arrow).
Fig. 2
Fig. 2
The macroscopic specimen is a grossly enlarged testis (65 mm × 50 mm × 50 mm). White nodular tumor components have replaced the normal testicular tissue.
Fig. 3
Fig. 3
Histopathological analyses. (a) The pathological specimen shows myeloma cell infiltration in the testis (hematoxylin and eosin stain). Immunohistochemistry staining is positive for (b) IgD and (c) light chain λ.
See this image and copyright information in PMC

References

    1. Savcikova S., Minarik J., Stork M., Jelinek T., Pour L., Hajek R. Extramedullary disease in multiple myeloma — controversies and future directions. Blood Rev. 2019 doi: 10.1016/j.blre.2019.04.002. - DOI - PubMed
    1. Gerecke C., Fuhrmann S., Strifler S., Schmidt-Hieber M., Einsele H., Knop S. The diagnosis and treatment of multiple myeloma. Dtsch Arzteblatt Int. 2016 https://doi.10.3238/arztebl.2016.0470 - PMC - PubMed
    1. Rosenberg S., Shapur N., Gofrit O., Or R. Plasmacytoma of the testis in a patient with previous multiple myeloma: is the testis a santuary site? J Clin Oncol. 2010 https://doi.10.1200/JCO.2009.27.6519 - PubMed
    1. Hwang Y.Y., Chim C.S., Shek T.W. Multiple myeloma with testicular involvement. J Clin Oncol. 2008 https://doi.10.1200/JCO.2007.15.1316 - PubMed
    1. Wei Z.L., Pac C.M., Jiang Y.Z., Yan-Dai, Huanguang L.Q., Huang D.P. Late relapse of multiple myeloma with testicular plasmacytoma after autologous hematopoietic stem cell transplantation: a case report and review of the literature. Ann Clin Lab Sci. 2018;48:120–125. - PubMed

Publication types

LinkOut - more resources