Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 28:23:103784.
doi: 10.1016/j.dib.2019.103784. eCollection 2019 Apr.

Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

María N Barrachina  1   2 , Irene Izquierdo  1   2 , Lidia Hermida-Nogueira  1   2 , Aurelio M Sueiro  3 , Esteban Guitián  4 , Felipe F Casanueva  2   3 , Richard W Farndale  5 , Masaaki Moroi  5 , Stephanie M Jung  5 , María Pardo  2   6 , Ángel García  1   2
Affiliations

Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

María N Barrachina et al. Data Brief. .

Abstract

This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.

PubMed Disclaimer

Figures

Data in Brief Figure 1
Fig. 1
Schematic workflow of the study.
See this image and copyright information in PMC

References

    1. Barrachina M.N., Sueiro A.M., Izquierdo I., Hermida-Nogueira L., Guitián E., Casanueva F.F., Farndale R.W., Moroi M., Jung S.M., Pardo M., García A. GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity. Atherosclerosis. 2019;281:62–70. - PMC - PubMed
    1. García A. Two-dimensional gel electrophoresis in platelet proteomics research, Methods. Mol. Med. 2007;139:339–353. - PubMed
    1. García A., Prabhakar S., Hughan S., Anderson T.W., Brock C.J. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood. 2004;103:2088–2095. - PubMed
    1. Shevchenko A., Jensen O.N., Podtelejnikov A.V., Sagliocco F., Wilm M. Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc. Natl. Acad. Sci. U.S.A. 1996;93:14440–14445. - PMC - PubMed
    1. Jensen L.J., Kuhn M., Stark M., Chaffron S., Creevey C. STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 2009;37:D412–D416. - PMC - PubMed

LinkOut - more resources