Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 11;11(7):1562.
doi: 10.3390/nu11071562.

Anti-Obesity Effect of Carotenoids: Direct Impact on Adipose Tissue and Adipose Tissue-Driven Indirect Effects

Lourdes Mounien  1 , Franck Tourniaire  1   2 , Jean-Francois Landrier  3   4
Affiliations
Review

Anti-Obesity Effect of Carotenoids: Direct Impact on Adipose Tissue and Adipose Tissue-Driven Indirect Effects

Lourdes Mounien et al. Nutrients. .

Abstract

This review summarizes current knowledge on the biological relevance of carotenoids and some of their metabolites in obesity management. The relationship between carotenoids and obesity is considered in clinical studies and in preclinical studies. Adipose tissue is a key organ in obesity etiology and the main storage site for carotenoids. We thus first describe carotenoid metabolism in adipocyte and adipose tissue and the effects of carotenoids on biological processes in adipose tissue that may be linked to obesity management in in vitro and preclinical studies. It is also now well established that the brain is strongly involved in obesity processes. A section is accordingly devoted to the potential effect of carotenoids on obesity via their direct and/or adipose tissue-driven indirect biological effects on the brain.

Keywords: adipocytes; adipose tissue; brain; carotenoids; obesity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of the main carotenoids.
Figure 2
Figure 2
Carotenoids effect on adipose tissue biology parameters, on brain and on adipose tissue–brain crosstalk.
See this image and copyright information in PMC

References

    1. The World Health Organization (WHO) Obesity and Overweight. WHO Media Center; Geneva, Switzerland: 2012.
    1. Arner E., Westermark P.O., Spalding K.L., Britton T., Ryden M., Frisen J., Bernard S., Arner P. Adipocyte turnover: Relevance to human adipose tissue morphology. Diabetes. 2010;59:105–109. doi: 10.2337/db09-0942. - DOI - PMC - PubMed
    1. Farmer S.R. Transcriptional control of adipocyte formation. Cell Metab. 2006;4:263–273. doi: 10.1016/j.cmet.2006.07.001. - DOI - PMC - PubMed
    1. Friedman J. 20 years of leptin: Leptin at 20: An overview. J. Endocrinol. 2014;223:T1–T8. doi: 10.1530/JOE-14-0405. - DOI - PubMed
    1. Ruhl R., Landrier J.F. Dietary regulation of adiponectin by direct and indirect lipid activators of nuclear hormone receptors. Mol. Nutr. Food Res. 2015;60:175–184. doi: 10.1002/mnfr.201500619. - DOI - PubMed

LinkOut - more resources