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. 1988;27(2):91-5.
doi: 10.1007/BF02138366.

Template-directed oligomerization of 3-isoadenosine 5'-phosphate

A R Hill Jr  1 , S Kumar, N J Leonard, L E Orgel
Collaborators, Affiliations

Template-directed oligomerization of 3-isoadenosine 5'-phosphate

A R Hill Jr et al. J Mol Evol. 1988.

Abstract

Template-directed oligomerization of an activated derivative of 3-isoadenosine 5'-phosphate (piA) on polyuridylic acid [poly(U)] was studied. The reaction of ImpiA is more efficient than the corresponding reaction of ImpA, and produces 3'-5'-linked oligomers while the reaction of ImpA gives only 2'-5'-linked oligomers. The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.

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References

    1. Science. 1985 May 3;228:585-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4398-402 - PubMed
    1. J Theor Biol. 1986 Nov 21;123(2):127-49 - PubMed
    1. Nucleic Acids Res. 1985 Apr 11;13(7):2469-84 - PubMed
    1. Biochim Biophys Acta. 1966 May 19;119(2):258-67 - PubMed

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