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Review
. 2019 Oct;21(5):e13154.
doi: 10.1111/tid.13154. Epub 2019 Aug 23.

Disseminated toxoplasmosis associated with hemophagocytic syndrome after kidney transplantation: A case report and review

Juliette Gay  1   2 , Nicolas Gendron  2   3   4 , Charles Verney  5 , Valentin Joste  1   2   6 , Marie-Laure Dardé  7   8 , Charlotte Loheac  5 , François Vrtovsnik  5   9 , Nicolas Argy  1   2   6 , Sandrine Houze  1   2   6
Affiliations
Review

Disseminated toxoplasmosis associated with hemophagocytic syndrome after kidney transplantation: A case report and review

Juliette Gay et al. Transpl Infect Dis. 2019 Oct.

Abstract

Disseminated toxoplasmosis is infrequent after kidney transplant transmission but life-threatening because of a lack of diagnostic suspicion as well as specific chemoprophylaxis recommendations. Solid organ transplantation has resulted in few cases of disseminated toxoplasmosis presenting with associated hemophagocytic syndrome. Herein, we report, within the context of a donor/receiver mismatch, a case of a toxoplasmosis associated with hemophagocytic syndrome in a kidney transplant recipient. Molecular and serological investigations confirmed Toxoplasma gondii transmission through the kidney graft.

Keywords: hemophagocytic syndrome; renal transplant; toxoplasmosis.

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References

REFERENCES

    1. Montoya JG, Liesenfeld O. Toxoplasmosis. The Lancet. 2004;363(9425):1965-1976.
    1. Lerolle N, Laanani M, Rivière S, et al. Diversity and combinations of infectious agents in 38 adults with an infection-triggered reactive haemophagocytic syndrome: a multicenter study. Clin Microbiol Infect. 2016;22(3):268.e1-8.
    1. Fishman JA, AST Infectious Diseases Community of Practice. Introduction: infection in solid organ transplant recipients. Am J Transplant. 2009;9(Suppl 4):S3-6.
    1. Fardet L, Galicier L, Lambotte O, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis & Rheumatology (Hoboken, NJ). 2014;66(9):2613-2620.
    1. Mary C, Faraut F, Lascombe L, Dumon H. Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity. J Clin Microbiol. 2004;42(11):5249-5255.

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