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Case Reports
. 2020 Feb;32(2):109-112.
doi: 10.1097/JXX.0000000000000251.

Necrotizing fasciitis associated with malignancy

Leon L Chen  1   2 , Kate Tayban  1 , Christopher Caravanos  1 , David Shaz  1 , Neil A Halpern  1
Affiliations
Case Reports

Necrotizing fasciitis associated with malignancy

Leon L Chen et al. J Am Assoc Nurse Pract. 2020 Feb.

Abstract

Necrotizing fasciitis (NF) is a rare soft-tissue condition with a high mortality rate even with treatment. Diagnosis is challenging due to an absence of specific symptoms at the early stages of clinical presentation. NF is typically associated with traumatic injuries, superficial skin breakdown, and surgical procedures. Diabetes mellitus and immunosuppression also increase the risk of developing NF. NF predominantly occurs in the lower extremities, the peritoneum, and the perineum. Treatments include antimicrobials, supportive care, and surgical source control. It is important for clinicians to recognize the association of spontaneous atraumatic NF caused by Clostridium septicum with malignancy, so they can maintain a high index of suspicion and provide timely interventions to optimize patient outcomes.

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