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. 2019 Aug 1;105(2):233-236.
doi: 10.1016/j.ajhg.2019.07.008.

Using the Data We Have: Improving Diversity in Genomic Research

Teri A Manolio  1
Affiliations

Using the Data We Have: Improving Diversity in Genomic Research

Teri A Manolio. Am J Hum Genet. .

Abstract

The shortage of genomic research data in persons of non-European ancestry is impeding our ability to use genomics in the clinical care of non-European individuals. Improved efforts to utilize data on non-European populations will increase the quality of genomic research and the inferences drawn from it for people of all backgrounds.

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Conflict of interest statement

The author is a member of the UK Biobank International Scientific Advisory Board and was a founder, and is now a funder, of the NHGRI-EBI GWAS Catalog and the PAGE Study.

Figures

Figure 1
Figure 1
Clustering of the 2,039 UK Individuals into 17 Clusters Based Only on Genetic Data For each individual, the colored symbol representing the genetic cluster to which the individual is assigned is plotted at the centroid of their grandparents’ birthplaces. Cluster names are in side-bars and ellipses give an informal sense of the range of each cluster. The tree (top right) depicts the order of the hierarchical merging of clusters (adapted from Leslie et al.7).
Figure 2
Figure 2
Population Substructure Present in the Multi-ethnic Sample of PAGE The population substructure present in the multi-ethnic sample of PAGE (n = 49,839), showing a continuum along principal components 1 and 2 that prevents meaningful stratification (adapted from Wojcik et al.10).
See this image and copyright information in PMC

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