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Comment
. 2019 Sep;30(9):569-571.
doi: 10.1016/j.tem.2019.07.017. Epub 2019 Jul 31.

Reconstitution of Organismal Liver Clock Function Requires Light

Takahito Miyake  1 , Masao Doi  2
Affiliations
Comment

Reconstitution of Organismal Liver Clock Function Requires Light

Takahito Miyake et al. Trends Endocrinol Metab. 2019 Sep.

Abstract

Recently Koronowski et al. (Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in vivo. This liver-autonomous metabolic cycling cannot be sustained under constant darkness, revealing the importance of the daily light cycle to restore liver function.

Keywords: Bmal1; autonomy; circadian; diurnal physiology; light; liver metabolism; systemic signaling.

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  • Defining the Independence of the Liver Circadian Clock.
    Koronowski KB, Kinouchi K, Welz PS, Smith JG, Zinna VM, Shi J, Samad M, Chen S, Magnan CN, Kinchen JM, Li W, Baldi P, Benitah SA, Sassone-Corsi P. Koronowski KB, et al. Cell. 2019 May 30;177(6):1448-1462.e14. doi: 10.1016/j.cell.2019.04.025. Cell. 2019. PMID: 31150621 Free PMC article.

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