Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Sep;9(9):1151-1152.
doi: 10.1158/2159-8290.CD-NB2019-089. Epub 2019 Aug 2.

New ADC Shrinks HER2-Positive Tumors

No authors listed
Comment

New ADC Shrinks HER2-Positive Tumors

No authors listed. Cancer Discov. 2019 Sep.

Abstract

A phase I trial reported positive results for an antibody-drug conjugate that targets HER2-positive tumors. Trastuzumab duocarmazine, which kills tumor cells by causing DNA damage, induced partial responses in 33% of patients whose tumors were resistant to the approved antibody-drug conjugate trastuzumab emtansine. The drug caused fatigue, neutropenia, pneumonitis, and eye-related side effects.

PubMed Disclaimer

Comment on