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Clinical Trial
. 2019 Sep;7(9):e898.
doi: 10.1002/mgg3.898. Epub 2019 Aug 3.

Research participants' experiences with return of genetic research results and preferences for web-based alternatives

Jill B Gaieski  1 , Linda Patrick-Miller  2   3 , Brian L Egleston  4 , Kara N Maxwell  1 , Sarah Walser  1 , Laura DiGiovanni  5 , Jamie Brower  5 , Dominique Fetzer  1 , Amanda Ganzak  1 , Danielle McKenna  1 , Jessica M Long  1 , Jacquelyn Powers  1 , Jill E Stopfer  5 , Katherine L Nathanson  5   6   7 , Susan M Domchek  1   5   7 , Angela R Bradbury  1   5   8
Affiliations
Clinical Trial

Research participants' experiences with return of genetic research results and preferences for web-based alternatives

Jill B Gaieski et al. Mol Genet Genomic Med. 2019 Sep.

Abstract

Background: While there is increasing interest in sharing genetic research results with participants, how best to communicate the risks, benefits and limitations of research results remains unclear.

Methods: Participants who received genetic research results answered open and closed-ended questions about their experiences receiving results and interest in and advantages and disadvantages of a web-based alternative to genetic counseling.

Results: 107 BRCA1/2 negative women with a personal or family history of breast cancer consented to receive genetic research results and 82% completed survey items about their experience. Most participants reported there was nothing they disliked (74%) or would change (85%) about their predisclosure or disclosure session (78% and 89%). They most frequently reported liking the genetic counselor and learning new information. Only 24% and 26% would not be willing to complete predisclosure counseling or disclosure of results by a web-based alternative, respectively. The most frequently reported advantages included convenience and reduced time. Disadvantages included not being able to ask questions, the risk of misunderstanding and the impersonal nature of the encounter.

Conclusion: Most participants receiving genetic research results report high satisfaction with telephone genetic counseling, but some may be willing to consider self-directed web alternatives for both predisclosure genetic education and return of results.

Keywords: genetic counseling; genetic testing; preferences for return of genetic research results; return of genetic research results; web-based alternatives to genetic counseling.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Study Flow Diagram
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