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Clinical Trial
. 1988;95(3):430-1.
doi: 10.1007/BF00181962.

Antidepressant effect of 5-methoxypsoralen: a preliminary report

E Souêtre  1 , E Salvati, J L Belugou, P Robert, G Brunet, G Darcourt
Affiliations
Clinical Trial

Antidepressant effect of 5-methoxypsoralen: a preliminary report

E Souêtre et al. Psychopharmacology (Berl). 1988.

Abstract

5-Methoxypsoralen (5 MOP) administered daily (40 mg at 9 p.m.) was compared with placebo in the treatment of severe depression. The clinical response was evaluated using the Hamilton Depression Rating Scale after 1 week of treatment. Our preliminary data indicate that patients receiving 5 MOP improved significantly after 1 week, whereas patients treated with placebo did not. The stimulating effect of 5 MOP on the melatonin secretion may be involved in this clinical effect.

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