Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep;40(3):561-572.
doi: 10.1016/j.ccm.2019.05.004.

Interstitial Lung Disease in Polymyositis and Dermatomyositis

Kathryn Long  1 , Sonye K Danoff  2
Affiliations
Review

Interstitial Lung Disease in Polymyositis and Dermatomyositis

Kathryn Long et al. Clin Chest Med. 2019 Sep.

Abstract

The idiopathic inflammatory myopathies (IIMs), including polymyositis (PM) and dermatomyositis (DM), are autoimmune connective tissue diseases with variable degrees of muscle inflammation and systemic involvement. Interstitial lung disease (ILD) is a common complication of the IIMs and is associated with increased mortality. Many patients with PM/DM have myositis-specific and myositis-associated antibodies (MSA/MAAs) that result in distinct clinical phenotypes. Among these MSAs, anti-aminoacyl-tRNA antibodies and anti-melanoma differentiation factor 5 antibodies have high rates of ILD. Corticosteroids are the mainstay of treatment, although the addition of other immunosuppressive therapy is typically necessary to achieve disease control.

Keywords: Dermatomyositis; Interstitial lung disease; Myositis; Polymyositis.

PubMed Disclaimer