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. 2019 Sep-Oct;47(5):499-505.
doi: 10.1016/j.aller.2019.03.004. Epub 2019 Jul 31.

Assessment of vitamin D status in common variable immunodeficiency or ataxia-telangiectasia patients

J R S Cruz  1 , R Silva  2 , I G A Andrade  1 , F L A Fonseca  3 , B T Costa-Carvalho  1 , R O S Sarni  4
Affiliations

Assessment of vitamin D status in common variable immunodeficiency or ataxia-telangiectasia patients

J R S Cruz et al. Allergol Immunopathol (Madr). 2019 Sep-Oct.

Abstract

Introduction and objectives: Vitamin D plays a role in the immune system, however studies regarding this are scarce. This study aimed to evaluate the nutritional status of vitamin D in patients with Common Variable Immunodeficiency (CVID) or Ataxia-Telangiectasia (A-T) and to relate it to body composition, inflammatory and bone metabolism markers.

Patients and methods: This is a cross-sectional and controlled study involving 24 patients of both sexes (59.3% male), aged 8-56 years, with CVID (n=15) or A-T (n=9). The following variables were evaluated: body mass index (BMI), 25-hydroxyvitamin D (25 (OH) D), hepatic profile, parathormone, calcium, phosphorus, alkaline phosphatase, interleukin 6 and high-sensitivity C-reactive protein.

Results: The median age was 26.0 years. A deficiency of 25 (OH) D was found in four A-T patients (44%) and two CVID patients (13%). Nine patients with CVI (60%) and six with A-T (66.7%) were overweight and underweight, respectively. There was a negative correlation between vitamin D and fat mass in the CVID group, and vitamin D and BMI in the A-T group. Vitamin D was negatively associated with the percentage of total fat among the patients (β - 0.842, 95% CI: -1.5-0.17, p=0.015), R2=0.21, after adjusting for sex and age.

Conclusion: Vitamin D deficiency occurred in a quarter of the patients although there was no difference between the patient and the control group; without association with bone and inflammation biomarkers. The percentage of fat and BMI were negatively associated with the concentrations of 25 (OH) D.

Keywords: Ataxia–telangiectasia; Body composition; Common variable immunodeficiency; Vitamin D.

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