Triclosan exposure and ovarian reserve

Abstract

The objective of the current analysis was to investigate the associations of urinary triclosan concentrations with parameters of ovarian reserve. Five hundred eleven female aged 25-39 years who attended the infertility clinic for diagnostic purposes were recruited. Urinary concentrations of triclosan were measured by a validated gas chromatograohy ion-tap mass spectrometry method. Parameters of ovarian reserve were: antral follicle count (AFC), anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E₂) levels. Urinary concentrations of triclosan decrease antral follicle count. There were no statistically significant associations between other parameters of ovarian reserve (estradiol, FSH and AMH levels) and triclosan concentrations. Triclosan exposure may negatively affect antral follicle count, a marker of ovarian reserve. As the data on triclosan exposure and ovarian reserve are scarce additional study is needed to confirm the results.

Keywords: Antral follicle count; Exposure to triclosan; Female fertility; Ovarian reserve.