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. 2019 Jul;65(1):47-51.
doi: 10.3164/jcbn.18-110. Epub 2019 Apr 18.

Effects of astaxanthin on VEGF level and antioxidation in human aqueous humor: difference by sex

Hirotaka Hashimoto  1 , Kiyomi Arai  2 , Jiro Takahashi  3 , Makoto Chikuda  2
Affiliations

Effects of astaxanthin on VEGF level and antioxidation in human aqueous humor: difference by sex

Hirotaka Hashimoto et al. J Clin Biochem Nutr. 2019 Jul.

Abstract

In our previous report, we showed the effect of astaxanthin intake on VEGF level in the aqueous humor and the relationship between VEGF level and reactive oxygen species-related parameters and other relevant factors. VEGF level is associated with total hydroperoxide level, and a multivariate analysis identified sex as a secondary factor affecting these relationships. Here, we analyzed the effects of astaxanthin on the relationship between VEGF level and reactive oxygen species-related parameters by sex. Patients (16 males and 19 females, aged 71.3 and 70.6, respectively) underwent bilateral cataract surgery on one side before and the other side after astaxanthin treatment (6 mg/day for 2 weeks). Levels of VEGF, hydrogen peroxide, and total hydroperoxide, and O2 •- scavenging activity, were measured in the aqueous humor. In females only, VEGF level was negatively correlated with O2 •- scavenging activity before the astaxanthin intake (r = -0.6, p<0.01) and positively correlated with total hydroperoxide level before and after the astaxanthin intake (r = 0.7 and 0.8, respectively, p<0.01). In conclusion, astaxanthin appears to affect O2 •- scavenging activity in the aqueous humor in females, and is likely to be involved in the control of VEGF levels in the anterior eye.

Keywords: VEGF; aqueous humor; astaxanthin; oxidation; superoxide.

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Conflict of interest statement

No potential conflicts of interest were disclosed.

Figures

Fig. 1
Fig. 1
Structural formula of astaxanthin.
Fig. 2
Fig. 2
Changes in parameters in aqueous humor before and after AX intake.
Fig. 3
Fig. 3
VEGF levels in aqueous humor before and after AX intake.
Fig. 4
Fig. 4
Relationship between superoxide scavenging activity and VEGF levels in aqueous humor.
Fig. 5
Fig. 5
Relationship between H2O2 and VEGF levels in aqueous humor.
Fig. 6
Fig. 6
Relationship between TH and VEGF levels in aqueous humor.
See this image and copyright information in PMC

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References

    1. Ohira A, Ueda T, Ohishi K, Hiramitsu T, Akeo K, Obara Y. Oxidative sutress in ocular disease. Nippon Ganka Gakkai Zasshi 2008; 112: 22–29 (in Japanese). - PubMed
    1. Moeller SM, Parekh N, Tinker L, et al. . Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women’s Health Initiative. Arch Ophthalmol 2006; 124: 1151–1162. - PubMed
    1. Hayashi M, Ishibashi T, Maoka T. Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals. J Clin Biochem Nutr 2018; 62: 195–205. - PMC - PubMed
    1. Tominaga K, Hongo N, Fujishita M, Takahashi Y, Adachi Y. Protective effects of astaxanthin on skin deterioration. J Clin Biochem Nutr 2017; 61: 33–39. - PMC - PubMed
    1. Hashimoto H, Takahashi J, Chikuda M, Obara Y. Anti-inflammatory effects of astaxanthin after cataract surgery. Atarashii Ganka 2007; 24: 1357–1360 (in Japanese).