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Review
. 2019 Jul 16:10:799.
doi: 10.3389/fphar.2019.00799. eCollection 2019.

Rubus chingii Hu: A Review of the Phytochemistry and Pharmacology

Guohua Yu  1   2 , Zhiqiang Luo  1   2 , Wubin Wang  2 , Yihao Li  2 , Yating Zhou  2 , Yuanyuan Shi  1   2
Affiliations
Review

Rubus chingii Hu: A Review of the Phytochemistry and Pharmacology

Guohua Yu et al. Front Pharmacol. .

Abstract

Rubus chingii Hu (R. chingii), referred to as "Fu-Pen-Zi" in Chinese, has great medicinal and dietary values since ancient times. The dried fruits of R. chingii have been widely used in traditional Chinese medicine (TCM) for the treatment of kidney enuresis and urinary frequency for centuries. According to current findings, R. chingii has been reported to contain a variety of chemical constituents, mostly triterpenoids, diterpenoids, flavonoids, and organic acids. These compounds have been demonstrated to be the major bioactive components responsible for pharmacological effects such as anticomplementary, anticancer, antioxidant, antimicrobial, and anti-inflammatory functions. Therefore, this review focused on the up-to-date published data of the literature about R. chingii and comprehensively summarized its phytochemistry, pharmacology, quality control, and toxicity to provide a beneficial support to its further investigations and applications in medicines and foods.

Keywords: Rubus chingii Hu; pharmacology; phytochemistry; quality control; toxicity.

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Figures

Figure 1
Figure 1
Chemical structures of triterpenoids (1–15) isolated from R. chingii.
Figure 2
Figure 2
Chemical structures of diterpenoids (16–30) isolated from R. chingii.
Figure 3
Figure 3
Chemical structures of flavonoids (31–48) isolated from R. chingii.
Figure 4
Figure 4
Chemical structures of alkaloids (49–55) isolated from R. chingii.
Figure 5
Figure 5
Chemical structures of volatile compounds (56–150) isolated from R. chingii.
Figure 6
Figure 6
Chemical structures of coumarins (151–155) isolated from R. chingii.
Figure 7
Figure 7
Chemical structures of steroids (156–154) isolated from R. chingii.
Figure 8
Figure 8
Chemical structures of organic acids (165–220) isolated from R. chingii.
Figure 9
Figure 9
Chemical structures of other compounds (221–235) isolated from R. chingii.
See this image and copyright information in PMC

References

    1. Azietaku J. T., Ma H., Yu X. A., Li J., Oppong M. B., Cao J., et al. (2017). A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum. J. Ethnopharmacol. 202, 241–255. 10.1016/j.jep.2017.03.022 - DOI - PubMed
    1. Bi W., Gao Y., Shen J., He C., Liu H., Peng Y., et al. (2016). Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): a review. J. Ethnopharmacol. 189, 31–60. 10.1016/j.jep.2016.04.021 - DOI - PubMed
    1. Cai Y. Q., Hu J. H., Qin J., Sun T., Li X. L. (2018). Rhododendron Molle(Ericaceae): phytochemistry, pharmacology, and toxicology. Chin. J. Nat. Med. 16, 401–410. 10.1016/S1875-5364(18)30073-6 - DOI - PubMed
    1. Cao F., Qiu X. X., Zhang L., Wang Y. Y. (2017). Determination of three triterpene acids in Rubi Fructus by reverse-phase high-performance liquid chromatography. J. Anhui. Univ. Chin. Med. 36, 79–82. 10.3969/j.issn.2095-7246.2017.04.023 - DOI
    1. Chai W. (2008). Studies on the chemical constituents and quality standard of Rubus chingii Hu. Ph.D Thesis. Beijing, China: China Academy of Chinese Medical Science.

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