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Review
. 2019 Jul 16:10:771.
doi: 10.3389/fneur.2019.00771. eCollection 2019.

Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?

Laura Papetti  1 , Fabiana Ursitti  1 , Romina Moavero  1   2 , Michela Ada Noris Ferilli  1 , Giorgia Sforza  2 , Samuela Tarantino  1 , Federico Vigevano  1 , Massimiliano Valeriani  1   3
Affiliations
Review

Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?

Laura Papetti et al. Front Neurol. .

Abstract

Migraine is a frequent and very disabling disease, especially at pediatric age. Despite this, there are few controlled data on the prophylactic treatment of primary headaches in this category of age. Given that the recently introduced calcitonin gene-related peptide (CGRP) inhibitors (CGRP-r) are still limited to adulthood, there is no drug with exclusive indication for migraine treatment in pediatric age. This raises several limitations in terms of adherence and effectiveness of the therapy. Moreover, the scenario is complicated by placebo response, which is larger in children and adolescents than in adults and often leads to an improvement in the attack frequency even in absence of any active pharmacological treatment. Our aim was to investigate the real evidence concerning the prophylactic therapy of pediatric migraine by reviewing the clinical studies published between 2010 and 2019.

Keywords: guidelines; migraine; pediatric migraine; preventive; prophylactic drugs; therapy; treatment.

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Figures

Figure 1
Figure 1
Flow diagram of the study methodology.
See this image and copyright information in PMC

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