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. 2019;8(3):363-371.
doi: 10.3233/JHD-199003.

Huntington's Disease Clinical Trials Corner: June 2019

Filipe B Rodrigues  1   2   3 , Joaquim J Ferreira  2   3   4 , Edward J Wild  1
Affiliations

Huntington's Disease Clinical Trials Corner: June 2019

Filipe B Rodrigues et al. J Huntingtons Dis. 2019.

Abstract

In this edition of the Huntington's Disease Clinical Trials Corner we expand on the HD-DBS and on the TRIHEP3 trials, and we list all currently registered and ongoing clinical trials in Huntington's disease.

Trial registration: ClinicalTrials.gov NCT02519036 NCT03761849 NCT02535884 NCT02453061.

Keywords: Huntington disease; clinical trials.

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Conflict of interest statement

FBR and EJW were sub-investigators on LEGATO-HD (NCT02215616), IONIS HTTRx (NCT02519036) and IONIS HTTRx OLE (NCT03342053), and are sub-investigators on the Roche GENERATION-HD (NCT03761849), Roche Natural History Study (NCT03664804) and Roche GEN-EXTEND (NCT03842969) trials, and EJW was a sub-investigator on the Amaryllis (NCT02197130). EJW is the chief investigator of the Roche GEN-PEAK trial (NCT04000594) and FBR is a sub-investigator. JJF was principal investigator on LEGATO-HD and on a trial of ethyl-eicosapentanoate in Huntington’s disease. The authors did not make use of confidential or privileged information: all materials included in this manuscript were collected from publicly available sources. FBR has provided consultancy services to GLG. EJW has participated in scientific advisory boards with Hoffmann-La Roche Ltd, Ionis, Shire, GSK, Wave Life Sciences, PTC Therapeutics, Takeda and Mitoconix. All honoraria were paid through UCL Consultants Ltd, a wholly owned subsidiary of UCL. Their Host Institution, University College London Hospitals NHS Foundation Trust, has received funds as compensation for conducting clinical trials for Ionis Pharmaceuticals, Pfizer and Teva Pharmaceuticals. Hoffman La Roche Ltd has supported UCL with research funding for EJW. In view of the support to both regular authors from Hoffman-La Roche Ltd, JJF was invited to be a co-author to ensure the sections on the Ionis/Roche program were suitably balanced.

JJF received grants from GlaxoSmithKline, Grunenthal, Fundação MSD (Portugal), TEVA, MSD, Allergan, Novartis, Medtronic. He received consultancy fees from GlaxoSmithKline, Novartis, TEVA, Lundbeck, Solvay, BIAL, Merck-Serono, Merz, Ipsen, Biogen, Acadia, Allergan, Abbvie, Sunovion Pharmaceuticals. He is employed by Faculdade de Medicina de Lisboa and CNS - Campus Neurológico Sénior. He also participated in advisory boards for Bial and expert testimony to Novartis.

References

    1. Heinrich-Heine University, KKS Netzwerk, Medtronic, The George Huntington Institute, EHDN, CHDI Foundation Inc. Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington’s Disease (HD). https://ClinicalTrials.gov/show/NCT02535884; 2014.
    1. Institut National de la Santé Et de la Recherche Médicale, Ultragenyx Pharmaceutical Inc. A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington’s Disease. https://ClinicalTrials.gov/show/NCT02453061; 2015.
    1. Rodrigues FB, Wild EJ. Clinical trials corner: September 2017. J Huntingtons Dis. 2017;6(3):255–63. - PMC - PubMed
    1. Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, et al. Targeting huntingtin expression in patients with huntington’s disease. The New England Journal of Medicine. 2019. - PubMed
    1. Hoffmann-La Roche. A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Patients With Manifest Huntington’s Disease. https://ClinicalTrials.gov/show/NCT03761849; 2018.

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