The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder

Abstract

Genetic and environmental factors play a role in the cause and development of attention-deficit/hyperactivity disorder (ADHD). Recent studies have suggested an important role of the gut-brain axis (GBA) and intestinal microbiota in modulating the risk of ADHD. Here, the authors provide a brief overview of the clinical and biological picture of ADHD and how the GBA could be involved in its cause. They discuss key biological mechanisms involved in the GBA and how these may increase the risk of developing ADHD. Understanding these mechanisms may help to characterize novel treatment options via identification of disease biomarkers.

Keywords: ADHD; Biomarkers; Endocrine communication; Genetics; Gut-brain axis; Immunology; Metabolites; Nerval communication.