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Case Reports
. 2019 Aug 4;12(8):e230082.
doi: 10.1136/bcr-2019-230082.

Respiratory epithelial adenomatoid hamartoma: a diagnostic challenge in sinonasal lesions

Shailesh Ramesh Agrawal  1 , Anagha Atul Joshi  1 , Nikhil Dhorje  1 , Renuka Bradoo  1
Affiliations
Case Reports

Respiratory epithelial adenomatoid hamartoma: a diagnostic challenge in sinonasal lesions

Shailesh Ramesh Agrawal et al. BMJ Case Rep. .

Abstract

Respiratory epithelial adenomatoid hamartoma (REAH) is a rare lesion in nasal cavity first reported by Wenig and Heffner in 1995. Most commonly seen in men in third to ninth decade of life. Majority of cases presents as a polypoidal mass in one or both nasal cavities. We experienced such a case of REAH originating from the nasal septum, in posterior aspect, treated by endoscopic approach. It is important to differentiate REAH from other sinonasal pathologies like inverted papilloma and low grade sinonasal adenocarcinoma. Complete surgical resection is the treatment of choice.

Keywords: nasal polyps; otolaryngology/ENT.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
(A) Diagnostic endoscopic picture of polyp on right side; (B) biopsy of polypoidal tissue with rubbery consistency medial to middle turbinate.
Figure 2
Figure 2
(A) Histopathological examination revealed polypoidal tissue lined by pseudostratified columnar epithelium beneath are glands lined by ciliated epithelium. (B) Magnified photo microscopic picture.
Figure 3
Figure 3
(A) Preoperation CT scan shows soft tissue sinus involving bilateral paranasal sinuses. (B) CT scan done after first surgery showing soft tissue density over the septum and in cribriform area.
See this image and copyright information in PMC

References

    1. Wenig BM, Heffner DK. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol 1995;104:639–45. 10.1177/000348949510400809 - DOI - PubMed
    1. Endo R, Matsuda H, Takahashi M, et al. Respiratory epithelial adenomatoid hamartoma in the nasal cavity. Acta Otolaryngol 2002;122:398–400. 10.1080/00016480260000085 - DOI - PubMed
    1. Delbrouck C, Fernandez Aguilar S, Choufani G, et al. Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis. Am J Otolaryngol 2004;25:282–4. 10.1016/j.amjoto.2004.02.005 - DOI - PubMed
    1. Sangoi AR, Berry G. Respiratory epithelial adenomatoid hamartoma: diagnostic pitfalls with emphasis on differential diagnosis. Adv Anat Pathol 2007;14:11–16. 10.1097/PAP.0b013e31802efb1e - DOI - PubMed
    1. Birt BD, Knight-Jones EB. Respiratory distress due to nasopharyngeal hamartoma. Br Med J 1969;3:281–2. 10.1136/bmj.3.5665.281 - DOI - PMC - PubMed

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