Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Apr-Jun;33(2):163-164.
doi: 10.1016/j.sjopt.2018.04.006. Epub 2018 Apr 26.

Corneal deposits following topical moxifloxacin use

Abdulaziz A Alshamrani  1 , Saad S Alharbi  1
Affiliations

Corneal deposits following topical moxifloxacin use

Abdulaziz A Alshamrani et al. Saudi J Ophthalmol. 2019 Apr-Jun.

Abstract

Corneal deposits have been reported with numerous topical medications including fluoroquinolones. However, they have not been documented as a side effect of topical moxifloxacin. In this report, we describe the first case of corneal deposits following the use of preservative-free topical moxifloxacin 0.5% eye drops in a 26-year-old male with keratoconus who underwent a unilateral corneal cross-linking. Increased frequency and prolonged instillation of moxifloxacin eye drops led to corneal precipitation in this patient. Complete resolution of corneal deposits occurred four months after drug discontinuation without sequelae.

Keywords: Corneal deposits; Fluoroquinolone; Moxifloxacin.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Moxifloxacin corneal deposits at presentation.
Fig. 2
Fig. 2
Complete resolution of the deposits after 4 months of drug discontinuation.
See this image and copyright information in PMC

References

    1. Andersson M.I., MacGowan A.P. Development of the quinolones. J Antimicrob Chemother. 2003 May;51(Suppl 1):1–11. - PubMed
    1. Vijay Zawar S., Mahadik S. Corneal deposit after topical ciprofloxacin as postoperative medication after cataract surgery. Can J Ophthalmol. 2014 Aug;49(4):392–394. - PubMed
    1. Mitra A., Tsesmetzoglou E., McElvanney A. Corneal deposits and topical ofloxacin–the effect of polypharmacy in the management of microbial keratitis. Eye (Lond) 2007 Mar;21(3):410–412. Epub 2006 Mar 17. - PubMed
    1. Elia M., Khodadadeh S., Chow J. Corneal crystalline deposits associated with topically applied gatifloxacin. Cornea. 2014 Jun;33(6):638–639. - PubMed
    1. Agarwal AK, Ram J, Singh R. Sparfloxacin-associated corneal epithelial toxicity. BMJ Case Reports. 2014;2014:bcr2014203786. - PMC - PubMed

LinkOut - more resources