Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug;33(3):155-161.
doi: 10.1055/s-0039-1693400. Epub 2019 Aug 2.

Platelet-Rich Plasma: Principles and Applications in Plastic Surgery

Amjed Abu-Ghname  1 , Aurelia Trisliana Perdanasari  1 , Matthew J Davis  1 , Edward M Reece  1
Affiliations
Review

Platelet-Rich Plasma: Principles and Applications in Plastic Surgery

Amjed Abu-Ghname et al. Semin Plast Surg. 2019 Aug.

Abstract

Platelet-rich plasma (PRP) is an autogenously harvested liquid platelet concentrate extracted from a patient's peripheral blood that contains higher than baseline concentrations of growth factors and cytokines. This innovative new technology has demonstrated great promise in the field of plastic surgery, and its use has been evaluated in several clinical settings including wound healing, hair restoration, and skin rejuvenation. The goal of this article is to explain the biology behind PRP and to review the basic principles involved in its preparation. This will be followed by a discussion of some clinical applications of PRP in both aesthetic and reconstructive plastic surgery.

Keywords: PRP; bone healing; growth factors; hair growth; platelet-rich plasma; skin rejuvenation; wound healing.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest None declared.

Figures

Fig. 1
Fig. 1
Schematic representation of the role of platelets in wound healing. MSCs, mesenchymal stem cells; PDGF, platelet-derived growth factor; TGF-β, transforming growth factor β.
See this image and copyright information in PMC

References

    1. Beasley L S, Einhorn T A. New York, NY: Lippincott Williams & Wilkins; 2000. Role of growth factors in fracture healing; pp. 311–322.
    1. Bhanot S, Alex J C. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg. 2002;18(01):27–33. - PubMed
    1. Anitua E, Andia I, Ardanza B, Nurden P, Nurden A T. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91(01):4–15. - PubMed
    1. Marx R E. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62(04):489–496. - PubMed
    1. Kevy S V, Jacobson M S. Comparison of methods for point of care preparation of autologous platelet gel. J Extra Corpor Technol. 2004;36(01):28–35. - PubMed