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Multicenter Study
. 2019 Jul 29:8:128.
doi: 10.1186/s13756-019-0573-8. eCollection 2019.

Near-ubiquitous presence of a vancomycin-resistant Enterococcus faecium ST117/CT71/ van B -clone in the Rhine-Main metropolitan area of Germany

Linda Falgenhauer  1 , Moritz Fritzenwanker  1 , Can Imirzalioglu  1 , Katrin Steul  2 , Marlene Scherer  2 ; Rhine-Main VREfm study group; Ursel Heudorf #  2 , Trinad Chakraborty #  1
Collaborators, Affiliations
Multicenter Study

Near-ubiquitous presence of a vancomycin-resistant Enterococcus faecium ST117/CT71/ van B -clone in the Rhine-Main metropolitan area of Germany

Linda Falgenhauer et al. Antimicrob Resist Infect Control. .

Abstract

Whole-genome sequencing analysis of Vancomycin-resistant Enterococcus faecium isolates from the Frankfurt metropolitan region revealed that 78/94 isolates were MLST type ST117, cgMLST complex type CT71 with a common vanB chromosomal insertion site. This indicates circulation of a single VRE clone in a catchment area of 5,000-km2 with 3 million inhabitants.

Keywords: ST117; VRE; WGS; cgMLST.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Minimum spanning tree of the sequenced VREfm isolates based on the cgMLST data. The figure was created according to reference [10]. Cluster distance threshold was set to 10 cgMLST alleles. Size of circles is according to number of isolates. Numbers in the circles indicate the complex type of the respective isolates. Colors of circles indicate multilocus sequence types
Fig. 2
Fig. 2
Minimum spanning tree of Cluster 1 based on cgMLST information. Different colours depict different clinics. Cluster distance threshold was set to 10 cgMLST alleles. Size of circles is representative and reflects the number of isolates
See this image and copyright information in PMC

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