Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul;31(105):203-208.

The Effect of Gelfoam Impregnated With Botulinum Toxin on Allergic Rhinitis

Vahid Zand  1 , Mohammadhossein Baradaranfar  1 , Mohammadhossein Dadgarnia  1 , Mojtaba Meybodian  1 , Sedighe Vaziribozorg  1 , Mohammad Mandegari  1 , Nasrin Behniafard  2 , Amrollah Dehghani  1
Affiliations

The Effect of Gelfoam Impregnated With Botulinum Toxin on Allergic Rhinitis

Vahid Zand et al. Iran J Otorhinolaryngol. 2019 Jul.

Abstract

Introduction: This study evaluated the effect of gelfoam impregnated with botulinum toxin on the symptoms induced by allergic rhinitis.

Materials and methods: In total, 30 patients with allergic rhinitis who did not respond to common therapies were included in this clinical trial study. All patients were treated with intranasal gelfoam impregnated with botulinum toxin type a (40 unit in each side) placed in the middle meatus of each nostril. The main symptoms of allergic rhinitis were scored from zero to three by the patients. Symptoms recorded and compared before and two months after the treatment.

Result: The mean age of patients was 31.03±6.9 years. The mean score for sneezing was 2.23 before the treatment which significantly decreased to 1.06 after the treatment (P<0.05). The mean scores of rhinorrhea, nasal congestion, and nasal itching were 2.53, 2.03, and 1.93, respectively, before the treatment which significantly decreased to 0.93, 1, and 0.8 after the treatment (P<0.05). No reported side effects was observed in this study.

Conclusion: According to the results, treatment with gelfoam impregnated with botulinum toxin is an effective and safe method in patients who have not responded to common therapies for allergic rhinitis. Accordingly, it is recommended to relieve symptoms in patients with seasonal allergic rhinitis in order to maintain the effectiveness of this treatment at least 8 weeks.

Keywords: Allergic rhinitis; Botulinum toxin; Gelfoam.

PubMed Disclaimer

Figures

Fig 1
Fig 1
gel foam placed in each nasal cavity
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bauchau V, Durham S. Prevalence and rate of diagnosis of allergic rhinitis in Europe. European Respiratory Journal. 2004;24(5):758–64. - PubMed
    1. Crystal-Peters J, Crown WH, Goetzel RZ, Schutt DC. The cost of productivity losses associated with allergic rhinitis. Am J Manag Care. 2000;6(3):373–8. - PubMed
    1. Okubo K, Kurono Y, Fujieda S, Ogino S, Uchio E, Odajima H, et al. Japanese guideline for allergic rhinitis. Allergology International. 2011;60(2):171–89. - PubMed
    1. Price D, Bond C, Bouchard J, Costa R, Keenan J, Levy ML, et al. International Primary Care Respiratory Group (IPCRG) guidelines: management of allergic rhinitis. Primary care respiratory journal. 2006;15(1):58–70. - PMC - PubMed
    1. Sardana N, Craig TJ. Congestion and sleep impairment in allergic rhinitis. Asian Pacific journal of allergy and immunology. 2011;29(4):297. - PubMed

LinkOut - more resources