A comprehensive review on biological activities of oxazole derivatives

Abstract

The utility of oxazole as intermediates for the synthesis of new chemical entities in medicinal chemistry have been increased in the past few years. Oxazole is an important heterocyclic nucleus having a wide spectrum of biological activities which drew the attention of researchers round the globe to synthesize various oxazole derivatives and screen them for their various biological activities. The present review article aims to review the work reported on therapeutic potentials of oxazole scaffolds which are valuable for medical applications during new millennium.

Keywords: Anticancer; Antimicrobial; Antitubercular; Oxazole derivatives.

Fig. 1

Marketed preparations containing oxazole

Fig. 2

Structures of the most active antimicrobial compounds

Fig. 3

Structures of the most active antimicrobial compounds

Fig. 4

Structures of the most active antimicrobial compounds

Fig. 5

Structures of the most active antimicrobial compounds

Fig. 6

Structures of the most active anticancer compounds

Fig. 7

Structures of the most active anticancer compounds

Fig. 8

Structures of the most active antitubercular and anti-inflammatory compounds

Fig. 9

Structures of the most active anti-inflammatory compounds

Fig. 10

Structures of the most active antidiabetic and antiobesity compounds

Fig. 11

Structure of the most active antioxidant compound, adrenergic receptor ligand, antiprogesterone compounds, prostacyclin receptor antagonist, T-type calcium channel blocker and transthyretin (TTR) amyloid fibril inhibitors