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. 1988 Aug 1;90(3):279-84.
doi: 10.1016/0304-3940(88)90202-9.

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

M D Majewska  1 , J M Mienville, S Vicini
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Free article

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

M D Majewska et al. Neurosci Lett. .
Free article

Abstract

Our earlier biochemical studies suggested that the neurosteroid pregnenolone sulfate (PS) may reduce gamma-aminobutyric acid (GABA) action at the Cl- channel associated with GABAA receptors. In the present electrophysiological study the interaction of PS with the GABAA receptor was tested, using whole-cell voltage-clamp recordings from isolated cerebral cortical neurons of neonatal rats. At micromolar concentrations PS reversibly inhibited GABA-induced current, behaving as an allosteric receptor antagonist.

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