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. 2019 Nov;126(12):1448-1454.
doi: 10.1111/1471-0528.15899. Epub 2019 Aug 25.

Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study

S Ikehara  1 , T Kimura  2 , A Kakigano  3 , T Sato  4 , H Iso  1 ; Japan Environment Children's Study Group
Collaborators, Affiliations

Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study

S Ikehara et al. BJOG. 2019 Nov.

Abstract

Objective: To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery.

Design: Prospective cohort study.

Setting: The Japan Environment and Children's Study (JECS).

Population: A total of 94 349 singleton pregnancies.

Methods: Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non-drinkers, consumers of 1-149 g, 150-299 g and ≥300 g ethanol/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (OR) and 95% CI were calculated relative to non-drinkers using logistic regression.

Main outcome measures: Medical record-based preterm delivery.

Results: Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (≥300 g ethanol/week) during the second and third trimesters was associated with a four-fold higher risk compared with non-drinkers (multivariable OR 4.52; 95% CI 1.68-12.2). Light alcohol consumption (1-149 g ethanol/week) tended to be associated with lower risk of preterm delivery (multivariable OR 0.78; 95% CI 0.60-1.00).

Conclusions: Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women.

Tweetable abstract: Heavy drinking during pregnancy may increase the risk of preterm delivery.

Keywords: Alcohol consumption; pregnant women; preterm delivery; prospective study; the Japan Environment and Children's Study (JECS).

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Figure 1
Participant selection flow chart.
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