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Review
. 2019 Sep;16(9):e1900366.
doi: 10.1002/cbdv.201900366. Epub 2019 Aug 30.

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Rainer Schobert  1 , Bernhard Biersack  1
Affiliations
Review

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Rainer Schobert et al. Chem Biodivers. 2019 Sep.

Abstract

The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.

Keywords: cancer; garcinol; infectious diseases; inflammation; isogarcinol.

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