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. 2019 Sep;6(9):1872-1876.
doi: 10.1002/acn3.50833. Epub 2019 Aug 6.

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Elena Antelmi  1   2 , Fabio Pizza  1   2 , Vincenzo Donadio  1   2 , Marco Filardi  1 , Yuri L Sosero  1 , Alex Incensi  2 , Stefano Vandi  1   2 , Monica Moresco  1   2 , Raffaele Ferri  3 , Sara Marelli  4   5 , Luigi Ferini-Strambi  4   5 , Rocco Liguori  1   2 , Giuseppe Plazzi  1   2
Affiliations

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Elena Antelmi et al. Ann Clin Transl Neurol. 2019 Sep.

Erratum in

Abstract

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

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Conflict of interest statement

G.P. participated in advisory board of UCB pharma, Jazz pharmaceuticals and Bioproject. All the other authors have nothing to disclose.

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