Genetics: Segregation of Mitochondrial Genomes in the Germline
- PMID: 31386851
- DOI: 10.1016/j.cub.2019.06.029
Genetics: Segregation of Mitochondrial Genomes in the Germline
Abstract
Mitochondrial genomes are present in hundreds of copies per cell. Recent work now reports the levels of inheritance of mtDNA heteroplasmy in humans and also explores mechanisms that restrict the inheritance of deleterious mtDNA variants in the Drosophila female germline.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline.Nature. 2019 Jun;570(7761):380-384. doi: 10.1038/s41586-019-1213-4. Epub 2019 May 15. Nature. 2019. PMID: 31092924 Free PMC article.
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Germline selection shapes human mitochondrial DNA diversity.Science. 2019 May 24;364(6442):eaau6520. doi: 10.1126/science.aau6520. Epub 2019 May 23. Science. 2019. PMID: 31123110
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