Maternal Inheritance: Longevity Programs Nourish Progeny via Yolk

Robert H Dowen¹, Shawn Ahmed²

Affiliations

¹ Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: dowen@email.unc.edu.
² Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: shawn@med.unc.edu.

PMID: 31386852
DOI: 10.1016/j.cub.2019.06.050

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Maternal Inheritance: Longevity Programs Nourish Progeny via Yolk

Robert H Dowen et al. Curr Biol. 2019.

Free article

. 2019 Aug 5;29(15):R748-R751.

doi: 10.1016/j.cub.2019.06.050.

Authors

Robert H Dowen¹, Shawn Ahmed²

Affiliations

¹ Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: dowen@email.unc.edu.
² Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: shawn@med.unc.edu.

PMID: 31386852
DOI: 10.1016/j.cub.2019.06.050

Abstract

Epigenetic effects can be mediated by changes in chromatin state that are transmitted from parent to child via gametes, but support is gathering for maternal yolk, which is deposited into ooctyes, as an extranuclear epigenetic factor that can contribute to phenotypic plasticity across generations in Caenorhabditis elegans.

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Insulin/IGF Signaling and Vitellogenin Provisioning Mediate Intergenerational Adaptation to Nutrient Stress.
Jordan JM, Hibshman JD, Webster AK, Kaplan REW, Leinroth A, Guzman R, Maxwell CS, Chitrakar R, Bowman EA, Fry AL, Hubbard EJA, Baugh LR. Jordan JM, et al. Curr Biol. 2019 Jul 22;29(14):2380-2388.e5. doi: 10.1016/j.cub.2019.05.062. Epub 2019 Jul 4. Curr Biol. 2019. PMID: 31280992 Free PMC article.

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R01 GM083048/GM/NIGMS NIH HHS/United States

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Maternal Inheritance: Longevity Programs Nourish Progeny via Yolk

Affiliations

Maternal Inheritance: Longevity Programs Nourish Progeny via Yolk

Authors

Affiliations

Abstract

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Grants and funding

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