Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

doi:10.1186/s13287-019-1357-z

Review

. 2019 Aug 6;10(1):238.

doi: 10.1186/s13287-019-1357-z.

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

Anwen Shao¹, Sheng Tu², Jianan Lu³, Jianmin Zhang^{3

4

5}

Affiliations

¹ Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China. 21118116@zju.edu.cn.
² Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
³ Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
⁴ Brain Research Institute, Zhejiang University, Hangzhou, 310003, China.
⁵ Collaborative Innovation Center for Brain Science, Zhejiang University, Hangzhou, 310003, China.

PMID: 31387621
PMCID: PMC6683526
DOI: 10.1186/s13287-019-1357-z

Review

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

Anwen Shao et al. Stem Cell Res Ther. 2019.

. 2019 Aug 6;10(1):238.

doi: 10.1186/s13287-019-1357-z.

Authors

Anwen Shao¹, Sheng Tu², Jianan Lu³, Jianmin Zhang^{3

4

5}

Affiliations

¹ Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China. 21118116@zju.edu.cn.
² Department of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
³ Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
⁴ Brain Research Institute, Zhejiang University, Hangzhou, 310003, China.
⁵ Collaborative Innovation Center for Brain Science, Zhejiang University, Hangzhou, 310003, China.

PMID: 31387621
PMCID: PMC6683526
DOI: 10.1186/s13287-019-1357-z

Abstract

The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury.

Keywords: Mechanism; Review; Spinal cord injury; Stem cell; Therapy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
The potential mechanism between stem cell and spinal cord injury

See this image and copyright information in PMC

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References

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1. Guertin PA. A central pattern generator in the spinal cord for the central control of micturition: an opportunity for first-in-class drug treatments. Asia Pac J Clin Trials Nerv Syst Dis. 2019;4:1–2. doi: 10.4103/2542-3932.251477. - DOI
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1. Donnelly DJ, Popovich PG. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol. 2008;209:378–388. doi: 10.1016/j.expneurol.2007.06.009. - DOI - PMC - PubMed
1. Badner A, Siddiqui AM, Fehlings MG. Spinal cord injuries: how could cell therapy help? Expert Opin Biol Ther. 2017;17:529–541. doi: 10.1080/14712598.2017.1308481. - DOI - PubMed

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[1] Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 1991;75:15–26. doi: 10.3171/jns.1991.75.1.0015. - DOI - PubMed

[2] Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 1991;75:15–26. doi: 10.3171/jns.1991.75.1.0015. - DOI - PubMed

[3] Guertin PA. A central pattern generator in the spinal cord for the central control of micturition: an opportunity for first-in-class drug treatments. Asia Pac J Clin Trials Nerv Syst Dis. 2019;4:1–2. doi: 10.4103/2542-3932.251477. - DOI

[4] Guertin PA. A central pattern generator in the spinal cord for the central control of micturition: an opportunity for first-in-class drug treatments. Asia Pac J Clin Trials Nerv Syst Dis. 2019;4:1–2. doi: 10.4103/2542-3932.251477. - DOI

[5] Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci. 2004;5:146–156. doi: 10.1038/nrn1326. - DOI - PubMed

[6] Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci. 2004;5:146–156. doi: 10.1038/nrn1326. - DOI - PubMed

[7] Donnelly DJ, Popovich PG. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol. 2008;209:378–388. doi: 10.1016/j.expneurol.2007.06.009. - DOI - PMC - PubMed

[8] Donnelly DJ, Popovich PG. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol. 2008;209:378–388. doi: 10.1016/j.expneurol.2007.06.009. - DOI - PMC - PubMed

[9] Badner A, Siddiqui AM, Fehlings MG. Spinal cord injuries: how could cell therapy help? Expert Opin Biol Ther. 2017;17:529–541. doi: 10.1080/14712598.2017.1308481. - DOI - PubMed

[10] Badner A, Siddiqui AM, Fehlings MG. Spinal cord injuries: how could cell therapy help? Expert Opin Biol Ther. 2017;17:529–541. doi: 10.1080/14712598.2017.1308481. - DOI - PubMed

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Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

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Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

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