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Review
. 2019 Aug 6;10(1):238.
doi: 10.1186/s13287-019-1357-z.

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

Anwen Shao  1 , Sheng Tu  2 , Jianan Lu  3 , Jianmin Zhang  3   4   5
Affiliations
Review

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

Anwen Shao et al. Stem Cell Res Ther. .

Abstract

The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury.

Keywords: Mechanism; Review; Spinal cord injury; Stem cell; Therapy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The potential mechanism between stem cell and spinal cord injury
See this image and copyright information in PMC

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