Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Dec;68(4):267-76.
doi: 10.1016/0041-3879(87)90067-5.

Bacteriostatic and bactericidal activity of ciprofloxacin and ofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex

L B Heifets  1 , P J Lindholm-Levy
Affiliations

Bacteriostatic and bactericidal activity of ciprofloxacin and ofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex

L B Heifets et al. Tubercle. 1987 Dec.

Abstract

MICs of ciprofloxacin were lower than MICs of ofloxacin for both M. tuberculosis and M. avium complex strains. The MICs of both drugs for 41 M. tuberculosis strains were in a narrow range, and significantly lower than the achievable serum concentrations. The MICs of ciprofloxacin for 46 M. avium strains were in a wide range, and in only 28% were the broth-determined MICs of ciprofloxacin within the same range as for M. tuberculosis and lower than the achievable serum level. When compared with the concentrations achievable in macrophages, the broth-determined MICs of ciprofloxacin were lower than this level for 61% of M. avium strains. Both drugs were bactericidal against M. tuberculosis and M. avium, with a low MIC/MBC ratio.

PubMed Disclaimer

Publication types

MeSH terms